Mann was born in San Francisco, California, and began her career at the age of 17, with appearances in television commercials. In 1995, Mann was chosen from an open audition of 500 candidates for her first big movie role in The Cable Guy (1996). Since then, she has starred in films such as George of the Jungle, Big Daddy, Stealing Harvard, The 40-Year-Old Virgin, Knocked Up, and 17 Again.
Mann will reunite with her Cable Guy co-star Jim Carrey in the upcoming film I Love You Phillip Morris,and Big Daddy co-star Adam Sandler in the upcoming film Funny People, as well as Knocked Up co-star Seth Rogen in the same film. Mann is set to star alongside Elizabeth Banks in What Was I Thinking?, based upon the book by Barbara Davilman and Liz Dubelman.
Mann is married to writer-director Judd Apatow, with whom she has two daughters, Iris and Maude. She met Apatow on the set of The Cable Guy (1996), which he co-wrote and produced.
Mann's daughters Iris and Maude appeared in Knocked Up, playing Mann's character's daughters. They will appear again as Mann's character's daughters in the upcoming Apatow film Funny People
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